CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-PI-0152-0001-1mg | $60 | ||
| VD-PI-0152-0005-5mg | $235 |
Z-L-Abu-CONH-ethyl
$60.00 – $235.00
Product Specification
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Appearance:
White to off-white solid.
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CAS Number:
N/A
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Cat.number:
VD-PI-0152
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Formula:
C21H31N3O5
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MW:
405.5
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Purity:
>98% by TLC.
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Calpain Inhibitor X; Z-Leu-Abu-CONHC2H5 (Abu = α-aminobutyric acid)
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Size:
1mg, 5mg
Description
A cell-permeable dipeptidyl α-ketoamide that acts as a potent, reversible, and active site inhibitor of calpain-1 and -2 (Ki ~ 250 nM). At 10-fold higher concentration it also inhibits cathepsin B (Ki = 2.4 µM). Has a neuroprotective role in the central nervous system following focal ischemia. Primary Target Ki – 250 nM.
1.James, T., et al. 1998. J. Neurosci. Res. 51, 218.
2.Bartus, R.T., et al. 1994. J. Cereb. Blood Flow Metab. 14, 537.
3.Li, Z., et al. 1993. J. Med. Chem. 36, 3472.
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