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PAC 1 (CAS 138605-00-2)




Product specification

Formula: C23H28N4O2
MW: 392.5
Purity: >98%
Appearance: White solid.
Solubility: 75 mM in 1eq. HCl and to 100 mM in DMSO.
Storage: +4˚C.
CAS Number: 315183-21-2
Synonyms: PAC-1,
Cat.number: VD-ESA-0022

Product Description

PAC 1 (CAS 315183-21-2) is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).



Product References
1. Putt et al (2006)  Nat.Chem.Biol. 2 543.
2. Peterson et al (2009)  J.Med.Chem. 52 5721.