Salubrinal

$60.00$100.00

Product Specification

  • Appearance
    :

    Beige solid

  • CAS Number
    :

    405060-95-9

  • Cat.number
    :

    VD-OEIA-0277

  • Formula
    :

    C21H17Cl3N4OS

  • MW
    :

    479.8

  • Purity
    :

    >=98% by (HPLC)

  • Solubility
    :

    DMSO

  • Storage
    :

    Store at +4°C

  • Synonyms
    :

    eIF-2α Inhibitor, SAL

  • Size
    :

    10mg, 5mg

Product Variations

Product # Price Quantity  
VD-OEIA-0277-0005-5mg $60
VD-OEIA-0277-0010-10mg $100

Description

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin. Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.

1.Boyce et al (2005). Science 307 935.
2.Long et al (2005). Bioorg.Med.Chem.Lett. 15 3849.

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