Product Variations
Product # | Price | Quantity | |
---|---|---|---|
VD-OEIA-0277-0005-5mg | $60 | ||
VD-OEIA-0277-0010-10mg | $100 |
$60.00 – $100.00
Beige solid
405060-95-9
VD-OEIA-0277
C21H17Cl3N4OS
479.8
>=98% by (HPLC)
DMSO
Store at +4°C
eIF-2α Inhibitor, SAL
10mg, 5mg
Product # | Price | Quantity | |
---|---|---|---|
VD-OEIA-0277-0005-5mg | $60 | ||
VD-OEIA-0277-0010-10mg | $100 |
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin. Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
1.Boyce et al (2005). Science 307 935.
2.Long et al (2005). Bioorg.Med.Chem.Lett. 15 3849.
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