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PEP 005 (CAS 75567-37-2)




Product specification

Formula: C25H34O6
MW: 430.53
Purity: >98%
Appearance: White solid.
Solubility: 2 mM in DMSO.
Storage: -20°C.
CAS Number: 75567-37-2
Synonyms: PEP 005, Ingenol-3-angelate
Cat.number: VD-ESA-0023

Product Description

PEP 005 (CAS 75567-37-2) is an activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells.

 




Product References
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4. Li et al (2010) T Cancer Res. 70 4509. PMID: 20460505.