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Angiotensin A (CAS 51833-76-2)




Product specification

Formula: C49H71N13O10
MW: 1002.18
Purity: >95%
Appearance: White lyophilised solid
Solubility: 1 mg/ml in water
Storage: -20°C.
CAS Number: 51833-76-2
Synonyms: AngiotensinA
Cat.number: VD-TMR-0002

Product Description

Angiotensin A (CAS 51833-76-2) is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (VD-TMR-0003) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as Angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).



Product References
1. Yang et al (2011) Hypertension 57 956. 
2. Coutinho et al (2013) J.Renin Angiotensin Aldosterone Syst. 5.
3. Villela et al (2014) Alamandine: Curr.Opin.Nephrol.Hypertens. 23 130.