Product # | Price | Quantity | Add to cart |
VD-TMR-0002-0010-10mg | 60 USD | ||
VD-TMR-0002-0050-50mg | 200 USD |
Angiotensin A (CAS 51833-76-2)
Product specification
Formula: | C49H71N13O10 |
MW: | 1002.18 |
Purity: | >95% |
Appearance: | White lyophilised solid |
Solubility: | 1 mg/ml in water |
Storage: | -20°C. |
CAS Number: | 51833-76-2 |
Synonyms: | AngiotensinA |
Cat.number: | VD-TMR-0002 |
Product Description
Angiotensin A (CAS 51833-76-2) is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (VD-TMR-0003) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as Angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).
Product References
1. Yang et al (2011) Hypertension 57 956.
2. Coutinho et al (2013) J.Renin Angiotensin Aldosterone Syst. 5.
3. Villela et al (2014) Alamandine: Curr.Opin.Nephrol.Hypertens. 23 130.
2. Coutinho et al (2013) J.Renin Angiotensin Aldosterone Syst. 5.
3. Villela et al (2014) Alamandine: Curr.Opin.Nephrol.Hypertens. 23 130.