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VD-TMR-0010-0010-10mg 230 USD
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FTIDC (CAS 873551-53-2)




Product specification

Formula: C18H23FN6O
MW: 358.41
Purity: >=98%.
Appearance: Pale cream solid
Solubility: 100 mM in DMSO.
Storage: -20°C.
CAS Number: 873551-53-2
Synonyms:
Cat.number: VD-TMR-0010

Product Description

FTIDC (CAS 873551-53-2) is a potent and selective mGlu1 receptor negative allosteric modulator (IC50 values are 5.8 and 6200 nM for mGlu1 and mGlu5 respectively). Also acts as an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu1-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.



Product References
1. Suzuki et al (2007) J.Pharmacol.Exp.Ther. 321 1144.
2. Ito et al (2008) Bioorg.Med.Chem. 16 9817.
3. Satow et al (2008) J.Pharmacol.Exp.Ther. 326 577.