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LSN 2463359 (CAS 1401031-52-4)




Product specification

Formula: C16H15N3O
MW: 265.31
Purity: >99%
Appearance: Off-white solid.
Solubility: 100 mM in DMSO and to 20 mM in ethanol
Storage: +4˚C.
CAS Number: 1401031-52-4
Synonyms: LSN2463359
Cat.number: VD-TMR-0011

Product Description

LSN 2463359 (CAS 1401031-52-4) is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908-induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.

 



Product References
1. Gastambide et al (2012) Neuropsychopharmacology 37 1057.
2. Gastambide et al (2013) Neuropharmacology 64 240.
3. Gilmour et al (2013) Neuropharmacology 64 224.