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VD-GFC-0123-0010-10mg 70 USD
VD-GFC-0123-0050-50mg 325 USD

VEGFR3 Kinase Inhibitor

Product specification

Formula: C21H18N2O
MW: 314.1
Purity: ≥95% by HPLC
Appearance: Red solid
Solubility: DMSO
Storage: +2°C to +8°C. Protect from light. Packaged under inert gas.
CAS Number:
Synonyms: MAZ51; Vascular Endothelial Growth Factor Receptor
3 Kinase Inhibitor
Cat.number: VD-GFC-0123

Product Description

A cell-permeable 3-substituted indolin-2-one compound that acts as an ATPcompetitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 M), it specifically blocks VEGF-C- and VEGF-D- induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 M). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis.

Product References
Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530.