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VD-Ant-0255-0001-1g 40 USD
VD-Ant-0255-0005-5g 170 USD

Cycloheximide




Product specification

Formula: C15H23NO4
MW: 281.35
Purity: ≥93.0% (HPLC)
Appearance: Off-white solid
Solubility: EtOH or MeOH
Storage: +15°C to +30°C
CAS Number: 66-81-9
Synonyms: Actidione, Naramycin A
Cat.number: VD-Ant-0255

Product Description

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome1.



Product References
Christner, C., et al. 1999. J. Med. Chem. 42, 3615. Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175. Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Waring, P. 1990. J. Biol. Chem. 265, 14476. Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174. Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.