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VD-AI-0269-0100-100mg 80 USD
VD-AI-0269-0300-300mg 200 USD

TPEN (CAS 16858-02-9)

Product specification

Formula: C26H28N6
MW: 424.6
Purity: >=97%
Appearance: Solid.
Solubility: Dimethyl formamide, DMSO, 100% Ethanol or Methanol.
Storage: +4°C to +8°C. Protect from light.
CAS Number: 16858-02-9
Synonyms: N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
Cat.number: VD-AI-0269

Product Description

TPEN (CAS 16858-02-9) is a cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 or QUIN 2/AM to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Complex with Fe2+ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in T cells.

Product References
1. P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985).
2. T. Nagano et al.; J. Biol. Chem. 264, 9243 (1989).