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VD-Ant-0336-0050-50mg 150 USD
VD-Ant-0336-0250-250mg 600 USD

Ac-D-Ala-D-lactic acid

Product specification

Formula: C8H13NO5
MW: 203.20
Purity: ≥95%
Storage: Longterm storage temperature: -20 ± 5 °C
CAS Number: 136577-05-4
Synonyms: Ac-D-Ala-D-Lac-OH
Cat.number: VD-Ant-0336

Product Description

Bacterial cell-wall peptide analog. In glycopeptide antibiotic-resistant enterococci (VanA and VanB types) the terminal sequence D-Ala-D-Ala is substituted by D-Ala-D-Lac leading to a 1000-fold decrease in affinity of a glycopeptide antibiotic to its target.

Product References
T.D.H.Bugg et al., Biochemistry, 30, 10408 (1991).
C.T.Walsh, Science, 261, 308 (1993).
S.S.Printsevskaya et al., J. Med. Chem., 45, 1340 (2002).