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VD-Ab-0008-100μg 460 USD

AIM (CT),(Apoptosis inhibitor of macrophages)


Synonyms:
Anti-Apoptosis Inhibitor of Macrophages, anti-AP16, anti-SP alpha, anti-CD5L.

Background:
Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C.parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.

Specificity:
Recognizes AIM.

Positive Control:
Raji cell lysate.

Species Reactivity:
Human and mouse. Other species not tested.

Host:
Rabbit

Immunogen:
A 13 amino acid peptide from near the carboxyterminus of human AIM (GenBank Accession No. AAD01446).

Format:
100 μg of polyclonal antibody in PBS containing 0.02% sodium azide. Purified by immunoaffinity chromatography.

Storage:
Store at 4°C.

Applications and Suggested Dilutions:
Western blot: Use at 0.5-1 μg/mL.
The optimal dilution for a specific application should be determined by the researcher.

Limitations:
For in vitro research use only. Not for use in diagnostics or in humans.

Warranty:
No warranties, expressed or implied, are made regarding the use of this product. VDM Biochemicals is not liable for any damage, personal injury, or economic loss caused by this product.