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VD-NP-0001-0010-10mg 65 USD
VD-NP-0001-0050-50mg 250 USD

Embelin




Product specification

Formula: C17H26O4

MW: 294.4
Purity: Single spot by TLC
Appearance: Orange solid
Solubility: DMSO or MeOH
Storage: +2°C to +8°C.
CAS Number: 550-24-3
Synonyms: Apoptosis Activator III
Cat.number: VD-NP-0001

Product Description

A cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 µM in a competitive binding assay with Smac peptide). Selectively induces caspase-9-mediated apoptosis in prostate cancer cells with high levels of XIAP (IC50 = 3.7 and 5.7 µM for PC-3 and LnCap, respectively), while exhibiting much less effect towards cells with low level XIAP (IC50 = 19.3 and 20.1 µM for WI-38 and PrEC, respectively). Also shown to sensitize XIAP overexpressing Jurkat cells to Etoposide -induced apoptosis. 



Product References
1.Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem. 47, 2430.