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VD-NP-0008-0005-5mg 60 USD
VD-NP-0008-0050-50mg 420 USD

Pifithrin-α, p-Nitro

Product specification

Formula:  C15H16BrN3O3• HBr
MW: 398.3
Purity: ≥97% by HPLC
Appearance: Beige solid
Solubility: DMSO or EtOH
Storage: -20°C. Protect from light. Packaged under inert gas. Hygroscopic.
CAS Number: 389850-21-9
Synonyms: 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-
imino-3(2H)-benzothiazolyl)ethanone, HBr
Cat.number: VD-NP-0008

Product Description

A cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro. Although its in vitro efficacy (ED50 = 0.3 µM in protecting etoposide-induced cortical neuron death) is similar to that of Pifithrin-α, it is 100-fold more potent than Pifithrin-α when adminstered in rats in vivo due to its long-lasting, steady conversion to the corresponding cyclic form of active compound in biological systems (t1/2 = 8h in neuron culture medium at 37°C.

Product References
Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.