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VD-NP-0007-0005-5mg 60 USD
VD-NP-0007-0050-50mg 420 USD

Bcl-2 Inhibitor II,YC137




Product specification

Formula: C24H21N3O6S2
MW: 511.57
Purity: ≥90% by HPLC
Appearance: Red solid
Solubility: DMSO or EtOH
Storage: -20°C. Protect from light. Packaged under inert gas.
CAS Number: 810659-53-1
Synonyms: YC137;
2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid
Cat.number: VD-NP-0007

Product Description

A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (<300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.



Product References

Real, P.J., et al. 2004. Cancer Res. 64, 7947.