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p53 Activator III, RITA (CAS 213261-59-7)




Product specification

Formula: C14H12O3S2
MW: 292.4
Purity: >=97%
Appearance: Crystalline solid.
Solubility: DMSO (3 mg/ml) or Ethanol (1 mg/ml).
Storage: +2°C to +8°C. Protect from light.
CAS Number: 213261-59-7
Synonyms: RITA; NSC 652287
Cat.number: VD-NP-0012

Product Description

p53 Activator III, RITA is a cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53.



Product References
1.Grinkevich, V., et al. 2005. Nat. Med. 11, 1136.
2.Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
3.Issaeva, N., et al. 2004. Nat. Med. 10, 1321.