Product # Price Quantity Add to cart
VD-AI-0277-0010-10mg 115 USD
VD-AI-0277-0100-100mg 1000 USD

Apoptosis Activator 2

Product specification

Formula: C15H9Cl2NO2
MW: 306.1
Purity: >=95% by HPLC
Appearance: Orange solid
Solubility: DMSO or MeOH
Storage: Protect from light. Packaged under inert gas.
CAS Number: 79183-19-0
Synonyms: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Cat.number: VD-AI-0277

Product Description

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Product References
1.Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.