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Indirubin-3'-oxime (CAS 160807-49-8)




Product specification

Formula: C16H11N3O2
MW: 277.28
Purity: ≥97% by HPLC
Appearance: Dark red solid
Solubility: 100 mM in DMSO and to 100 mM in Ethanol
Storage: -20°C. Protect from light.
CAS Number: 160807-49-8
Synonyms: Indirubin-3'-monoxime
Cat.number: VD-IS-0038

Product Description

Indirubin-3'-oxime (CAS 160807-49-8) is a protein kinase inhibitor: inhibits cyclin-dependent kinases (IC50 = 0.18-3.33 mM) and GSK-3b (IC50 = 0.19 mM). Inhibits CDK5- and GSK-3b-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.  



Product References
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2. Leclerc et al (2001) J.Biol.Chem. 276 251.
3. Bain et al (2003) Biochem.J. 371 199. 
Bain, J., et al. 2003. Biochem. J. 371, 199.
4. Leclerc, S., et al. 2000. J. Biol. Chem. 276, 251.
5. Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.