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STAT5 Inhibitor (CAS 285986-31-4)

Product specification

Formula: C16H11N3O3
MW: 293.3
Purity: ≥97%.
Appearance: White solid.
Solubility: DMSO (10 mg/ml).
Storage: +2°C to +8°C. Protect from light.
CAS Number: 285986-31-4
Synonyms: (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
Cat.number: VD-NP-0143

Product Description

STAT5 Inhibitor (CAS 285986-31-4) is a cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50=47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50>500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells. Solutions are stable for up to 3 months at -20°C.

Product References
1. Muller, J., et al. 2008. ChemBioChem 9, 723.