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VD-AM-0054-0010-10mg 70 USD
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SU 16f (CAS 251356-45-3)




Product specification

Formula: C24H22N2O3
MW: 386.44
Purity: ≥98 %
Appearance: Red-brown solid
Solubility: 100 mM in DMSO
Storage: RT
CAS Number: 251356-45-3
Synonyms: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-
3-ylidene)methyl ]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Cat.number: VD-AM-0054

Product Description

SU 16f (CAS 251356-45-3) is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).



Product References
1. Sun et al (1999) J.Med.Chem. 42 5120.