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SANT-1 (CAS 304909-07-7)




Product specification

Formula: C23H27N5
MW: 373.49
Purity: >=99% by (HPLC)
Appearance: Pale yellow solid
Solubility: 25 mM in Ethanol and to 50 mM in DMSO.
Storage: -20°C.Protect from light.
CAS Number: 304909-07-7
Synonyms: Not available.
Cat.number: VD-OEIA-0059

Product Description

SANT-1 (CAS 304909-07-7) is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). 



Product References
1.Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci.USA. 99 14071.