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NU 2058 (CAS 161058-83-9)




Product specification

Formula: C12H17N5O
MW: 247.3
Purity: ≥98% (HPLC)
Appearance: White solid
Solubility: 100 mM in DMSO, 10 mM in EtOH
Storage: +2°C to +8°C.
CAS Number: 161058-83-9
Synonyms: O6-Cyclohexylmethylguanine
Cat.number: VD-CCR-0077

Product Description

NU 2058 (CAS 161058-83-9) is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).



Product References
1. Arris et al (2000) J.Med.Chem. 43 2797.
2. Knockaert et al (2002) TiPS 23 417.
3. Jensen et al (2005) Cancer Res. 65 7470. 
4. Gibson, A. E., et al, J. Med. Chem. 45, 3381-3393 , (2002). 
5. Knockaert, M., et al, Trends Pharmacol. Sci. 23, 417-425, (2002).