CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| $170 | |||
| $650 |
(±)-AMG 487 (CAS 473719-41-4)
$170.00 – $650.00
Product Specification
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Appearance:
White solid.
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CAS Number:
473719-41-4
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Cat.number:
VD-AM-0057
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Formula:
C32H28F3N5O4
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MW:
603.59
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Purity:
>=98%.
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Solubility:
100 mM in DMSO.
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Storage:
-20°C.Protect from light.
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Synonyms:
Not available.
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Size:
10mg, 50mg
Description
(±)-AMG 487 (CAS 473719-41-4) is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.
1. Walser et al (2006); Cancer Res. 66 7701.
2. Johnson et al (2007); Bioorg.Med.Chem.Lett. 17 3339.
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