CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-00107-0500-500 µg | $180 | ||
| VD-OEIA-00107-0005-3mg | $700 |
γ-Secretase Inhibitor XXI, Compound E
$180.00 – $700.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
209986-17-4
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Cat.number:
VD-OEIA-00107
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Formula:
C27H24F2N4O3
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MW:
490.5
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Purity:
≥95%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Compound E
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Size:
3mg, 500 µg
Description
A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC50=300 pM for Aβ40 in CHO cells overexpressing wild type βAPP; 240 pM for Aβ40, 370 pM for Aβ42, and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP695 and mNotchΔE(M1727V); 100 pM for both Aβ40 and Aβ42 in SH-SY5Y cells stably transfected with SPA4CT).
1.Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
2.Jung, K.M., et al. 2003. J. Biol. Chem. 278, 42161.
3.Murakami, D., et al. 2003. Oncogene 22, 1511.
4.Campbell, W.A., et al. 2003. J. Neurochem. 85, 1563.
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