CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-ESA-0014-0010-10mg | $60 | ||
| VD-ESA-0014-0050-50mg | $280 |
A-769662 (CAS 844499-71-4)
$60.00 – $280.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
844499-71-4
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Cat.number:
VD-ESA-0014
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Formula:
C20H12N2O3S
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MW:
360.39
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Purity:
>=98%
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Solubility:
100 mM in DMSO and to 10 mM in ethanol.
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Storage:
+4˚C
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Synonyms:
A 769662
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Size:
10mg, 50mg
Description
A 769662 (CAS 844499-71-4) is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs.
1. Cool et al (2006) Cell Met. 3 403.
2. Sanders et al (2007) J.Biol.Chem. 282 32539.
3. Scott et al (2008) Chem.Biol. 15 1220.
4. Vazquez-Martin et al (2012) Cell Cycle 5 974.
5. de Meester et al (2014) Cardiovasc.Res. 101 20.
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