CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10024-0010-10mg | $160 | ||
| VD-OEIA-10024-0025-25mg | $320 |
Ac-KPR-AFC
$160.00 – $320.00
Product Specification
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Appearance:
White Solid
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CAS Number:
N/A
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Cat.number:
VD-OEIA-10024
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Formula:
C29H39F3N8O6
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MW:
652.66
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Purity:
>=98%
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Solubility:
DMSO/DMF
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Storage:
-20°C
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Synonyms:
AC-LYS-PRO-ARG-7-amino-4-trifluoromethylcoumarin
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Size:
10mg, 25mg
Description
N-Acetyl-Lys-Pro-Arg 7-Amino-4-trifluoromethylcoumarin is a fluorogenic substrate suitable for the assay of tryptase. When Ac-KPR-AFC is hydrolyzed, the free AFC produced in the reaction can be quantified by fluorometric detection (excitation 400 nm, emission 505 nm) or by spectrophotometric detection at 380 nm (extinction coefficient = 12,600 at pH 7.2). When used in an enzyme assay with fluorescence detection, AFC has higher sensitivity than 4-methoxy-2-naphthylamide (MNA).
1.Cushman, D.W., and Cheung, H. S., Biochem. Pharm., 20, 1637-1648 (1971).
2.Johansen, H. T., et al. Anal. Biochem., 273, 278-283 (1999).
3.Pallaoro, M., et al. J. Biol Chem., 274, 3355 (1999).
4.Caughey, G. H., et al.J. Immunol., 164, 6566-75 (2000).
5.Harris, J. L., et al. J. Biol. Chem., 276, 34941-34947 (2001).
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