CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0049-0010-10mg | $70 | ||
| VD-IS-0049-0050-50mg | $300 |
AG 99 (CAS 122520-85-8)
$70.00 – $300.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
122520-85-8
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Cat.number:
VD-IS-0049
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Formula:
C10H8N2O3
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MW:
204.18
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Purity:
≥99%
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Solubility:
5 mM in EtOH and to 100 mM in DMSO
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Storage:
+4°C.
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Synonyms:
Tyrphostin 46
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Size:
10mg, 50mg
Description
AG 99 (CAS 122520-85-8) is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
1. Gazit et al (1989) J.Med.Chem. 32 2344.
2. Levitzki and Gilon (1991) TiPS 12 171.
3. Gazit (1996) J.Med.Chem. 39 4905.
4. Yamamoto et al (2006) J.Cell Sci. 119 4623.
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