CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-PI-0095-0010-10mg | $90 | ||
| VD-PI-0095-0050-50mg | $400 |
AM 580
$90.00 – $400.00
Product Specification
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Appearance:
White crystalline solid
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CAS Number:
102121-60-8
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Cat.number:
VD-PI-0095
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Formula:
C22H25NO3
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MW:
351.44
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Purity:
>=95% by HPLC
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Solubility:
50 mM in DMSO
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Storage:
RT. Keep cool and dry.
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Synonyms:
4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalen yl)carboxamido]benzoic acid
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Size:
10mg, 50mg
Description
An analog of retinoic acid that acts as a selective Retinoic Acid Receptors RARα agonist (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro.
1.Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182.
2.Dawson et al (2008) The retinoic acid receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production. BMC Immunol. 9 16. Charton et al (2009) Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorg.Med.Chem.Lett. 19 489.
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