CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1029-0005-5mg | $150 | ||
| VD-OEIA-1029-0025-25mg | $550 |
Aurora A inhibitor II
$150.00 – $550.00
Product Specification
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Appearance:
N/A
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CAS Number:
1158838-43-7
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Cat.number:
VD-OEIA-1029
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Formula:
C31H29ClFN7O3
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MW:
602.6
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Purity:
>99%
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Solubility:
N/A
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Storage:
N/A
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Synonyms:
4-((2-((4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenyl)amino)- 5-fluoropyrimidin-4-yl)amino)-N-(2-chlorophenyl)benzamide
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Size:
25mg, 5mg
Description
Potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 4.3 nM (Aurora A) and unusually high selectivity 860 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases. This ligand has much higher selectivity of Aurora A vs Aurora B than another recently described relatively selective Aurora A inhibitor MLN8054, which shows 43-fold selectivity for Aurora A over Aurora B in enzymatic assays.
1. Aliagas-Martin et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J. Med. Chem. 2009, 52(10), 3300-7.
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