CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1031-0005-5mg | $220 | ||
| VD-OEIA-1031-0050-50mg | $850 |
Aurora Kinase/Cdk Inhibitor
$220.00 – $850.00
Product Specification
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Appearance:
White Solid
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CAS Number:
443797-96-4
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Cat.number:
VD-OEIA-1031
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Formula:
C15H12F2N6O3S • CH3CN
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MW:
435.4
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Purity:
≥97%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
4-(5-Amino-1-(2,6-difluorobenzoyl)-1H- [1,2,4]triazol-3-ylamino)-benzenesulfonamide
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Size:
50mg, 5mg
Description
A cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk’s (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 – 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
1. Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
2. Lin R., et al. 2005. J. Med. Chem. 48, 4208.
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