CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1052-0005-5mg | $300 | ||
| VD-OEIA-1052-0025-25mg | $1200 |
AZ 960
$300.00 – $1,200.00
Product Specification
-
Appearance:
Powder.
-
CAS Number:
905586-69-8
-
Cat.number:
VD-OEIA-1052
-
Formula:
C18H16F2N6
-
MW:
354.36
-
Purity:
>=98%
-
Solubility:
DMSO 70mg/ml, Water 1mg/ml.
-
Storage:
-20°C.Protect from light.
-
Synonyms:
AZ960
-
Size:
25mg, 5mg
Description
AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively. AZ960 was also shown to be active against other kinases, including TrkA, Aurora-A, and FAK, with IC50 of around 0.1 μM. AZ960, a novel inhibitor of Jak2 kinase, effectively induced growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1–infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1.
1. Mol Cancer Ther (2010);9:3386-3395.
Reviews
There are no reviews yet.