CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-PI-0153-0001-1mg | $66 | ||
| VD-PI-0153-0005-5mg | $260 |
Calpain Inhibitor XI
$66.00 – $260.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
145731-49-3
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Cat.number:
VD-PI-0153
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Formula:
C26H40N4O6
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MW:
504.6
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Purity:
>=95%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Z-Leu-Abu-CONH(CH2)3-morpholine (Abu = α-aminobutyric acid)
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Size:
1mg, 5mg
Description
A cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
1.Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
2.DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
3.Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
2.DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
3.Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
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