CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10012-0001-1mg | $60 | ||
| VD-OEIA-10012-0010-10mg | $450 |
Ceramide Kinase Inhibitor, K1
$60.00 – $450.00
Product Specification
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Appearance:
Yellow powder
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CAS Number:
1258005-85-4
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Cat.number:
VD-OEIA-10012
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Formula:
C21H28O4
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MW:
344.4
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Purity:
>=95%
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Solubility:
EtOH
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Storage:
-20°C. Protect from light.
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Synonyms:
F-12509A Cyclic Product K1
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Size:
10mg, 1mg
Description
A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50=~5 µM) with little effect against SPHK1/2 or DGKγ (IC50>100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.
1.Kim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
2.Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581.
3.Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
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