CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-ESA-0006-0010-10mg | $40 | ||
| VD-ESA-0006-0100-100mg | $340 |
Clofarabine (CAS 123318-82-1)
$40.00 – $340.00
Product Specification
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Appearance:
White Solid
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CAS Number:
123318-82-1
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Cat.number:
VD-ESA-0006
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Formula:
C10H11ClFN5O3
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MW:
303.68
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Purity:
>99%
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Solubility:
10 mM in water and to 100 mM in DMSO
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Storage:
+4˚C
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Synonyms:
Clolar, Evoltra, 2-Chloro-9-(2-deoxy-2-fluoro- β-D-arabinofuranosyl)-9H-purin-6-amine
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Size:
100mg, 10mg
Description
Clofarabine (CAS 123318-82-1) is a deoxycistidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
1.Parker et al (1991) Cancer Res. 51 2386.
2.Carson et al (1992) Proc.Natl.Acad.Sci.USA 89 2970.
3.Bonate et al (2006) Nat.Rev.Drug Discov. 5 855.
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