CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0040-0010-10mg | $70 | ||
| VD-CCR-0040-0050-50mg | $300 |
Dynasore (CAS 304448-55-3)
$70.00 – $300.00
Product Specification
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Appearance:
Pale yellow solid
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CAS Number:
304448-55-3
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Cat.number:
VD-CCR-0040
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Formula:
C18H14N2O4
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MW:
322.32
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Purity:
≥98% by HPLC
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Solubility:
100 mM in DMSO, 5 mM in EtOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
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Size:
10mg, 50mg
Description
Dynasore (CAS 304448-55-3) is a cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane. Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
1. Macia et al (2006) Develop.Cell 10 839.
2. Thompson and McNiven (2006) Nat.Chem.Biol. 2 355.
3. Newton et al (2006) Proc.Natl.Acad.Sci.USA 103 17955.
4. Young, A., et al. 2009. Biochem. J. , In press.
5. Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
6. Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
7. Macia. E., et al. 2006. Dev. Cell 10, 839.
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