CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0018-0005-5mg | $70 | ||
| VD-OEIA-0018-0050-50mg | $600 |
GSK-3β Inhibitor I
$70.00 – $600.00
Product Specification
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Appearance:
White Solid
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CAS Number:
327036-89-5
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Cat.number:
VD-OEIA-0018
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Formula:
C10H10N2SO2
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MW:
222.26
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Purity:
≥98%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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Size:
50mg, 5mg
Description
A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5 µM and 673 nM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
1.Guzman, M.L., et al. 2007. Blood 110, 4436.
2.Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
3.Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.
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