CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0016-0001-1mg | $70 | ||
| VD-OEIA-0016-0010-5mg | $300 |
GSK-3 Inhibitor X
$70.00 – $300.00
Product Specification
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Appearance:
Dark purple solid
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CAS Number:
740841-15-0
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Cat.number:
VD-OEIA-0016
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Formula:
C18H12BrN3O3
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MW:
398.2
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Purity:
≥97%
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
BIO-Acetoxime
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Size:
1mg, 5mg
Description
An acetoxime analog of BIO, GSK-3 Inhibitor IX that exhibits greater selectivity for GSK-3α/β (IC50=10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50=2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50≥10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50=0.16 µM) reporter systems.
1.Knockaert, M., et al. 2004. Oncogene 23, 4400.
2.Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
3.Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
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