CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0025-0005-5mg | $60 | ||
| VD-OEIA-0025-0050-50mg | $550 |
Histone Deacetylase Inhibitor II
$60.00 – $550.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
174664-65-4
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Cat.number:
VD-OEIA-0025
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Formula:
C10H10N2O4
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MW:
222.2
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Purity:
≥95%
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Solubility:
DMSO
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Storage:
-20°C. Protect from light.
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Synonyms:
m-Carboxy Cinnamic Acid bis-Hydroxamide, CBHA
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Size:
50mg, 5mg
Description
A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 M). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
1.Coffey, D.C., et al. 2001. Cancer Res. 61, 3591.
2.Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
3.Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
4.Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
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