CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0037-0003-5mg | $180 | ||
| VD-OEIA-0037-0050-50mg | $1350 |
Lck Inhibitor II
$180.00 – $1,350.00
Product Specification
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Appearance:
Light yellow solid
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CAS Number:
918870-43-6
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Cat.number:
VD-OEIA-0037
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Formula:
C24H26N6O3
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MW:
446.51
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Purity:
>=97%
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Solubility:
DMSO and EtOH
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)- pyrimidin-4-ylamino)-4-methylphenol
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Size:
50mg, 5mg
Description
A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50=3 nM; [ATP] = 10 µM). Has been reported to block IL-2 release in Jurkat E6-1 T cell line (IC50=54 nM) stimulated by CD3 cross-linking and PMA.
1.Sabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16: 5973-5977.
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