Product Variations
Product # | Price | Quantity | |
---|---|---|---|
VD-GFC-0032-0005-500μg | $148 | ||
VD-GFC-0032-0001-1mg | $200 |
$148.00 – $200.00
White Solid
VD-GFC-0032
C12H9F3N2O3
286.21
≥95% by HPLC
DMSO
+2°C to +8°C. Protect from Light. Packaged under inert gas.
Chemical name: α-Cyano-β-hydroxy-β-methyl-N-[4-(trifluoromethoxy)phenyl]propenamide
1mg, 500μg
Product # | Price | Quantity | |
---|---|---|---|
VD-GFC-0032-0005-500μg | $148 | ||
VD-GFC-0032-0001-1mg | $200 |
A potent and specific inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase in vitro (IC50 = 1.7 M). Kills over 99% of human breast cancer cells in vitro by triggering apoptosis. Even at high concentrations (175-350 M), LFM-A12 does not affect the enzymatic activity of other PTKs including BTK, HCK, IRK, JAK1, JAK3, and Syk.
Ghosh, S., et al. 1999. Clin. Cancer Res. 5, 4264. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Ghosh, S., et al. 1998. Clin. Cancer Res. 4, 2657.
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