Product Variations
Product # | Price | Quantity | |
---|---|---|---|
VD-AM-0102-0001-1mg | $110 | ||
VD-AM-0102-0005-5mg | $500 |
$110.00 – $500.00
White to off-white solid.
451462-58-1
VD-AM-0102
C16H21N3O2S.2HCl
392.34
≥98%
Soluble to 100 mM in H2O and to 50 mM in DMSO
+4°C.
Not available.
1mg, 5mg
Product # | Price | Quantity | |
---|---|---|---|
VD-AM-0102-0001-1mg | $110 | ||
VD-AM-0102-0005-5mg | $500 |
H 1152 dihydrochloride (CAS 451462-58-1) is a Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea-pig aorta (IC50 = 190 nM) and displays proerectile effects in rats.
1. Shum et al (2003) Br.J.Pharmacol. 139 1449.
2. Teixeira et al (2005) J.Pharmacol.Exp.Ther. 315 155.
3. Tamura et al (2005) Biochim.Biophys.Acta 1754 245.
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