CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-00097-0001-1g | $35 | ||
| VD-OEIA-00097-0010-10g | $250 |
Myeloperoxidase Inhibitor-I
$35.00 – $250.00
Product Specification
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Appearance:
Off-white crystalline solid
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CAS Number:
5351-17-7
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Cat.number:
VD-OEIA-00097
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Formula:
C7H9N3O
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MW:
151.2
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Purity:
≥95%
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Solubility:
DMSO or Dilute Acids
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Storage:
-20°C
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Synonyms:
4-aminobenzohydrazide
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Size:
10g, 1g
Description
A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
1.Engelmann, I., et al. 2000. Redox Report 5, 207.
2.Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
3.Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
4.Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
5.Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
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