CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10005-0005-5mg | $100 | ||
| VD-OEIA-10005-0025-25mg | $350 |
NF-kB Activation Inhibitor VI
$100.00 – $350.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
113760-29-5
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Cat.number:
VD-OEIA-10005
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Formula:
C15H15NO2S
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MW:
273.4
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Purity:
≥95%
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Solubility:
DMSO or EtOH
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Storage:
-20°C. Protect from light.
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Synonyms:
BOT-64; (Z)-6,6-dimethyl-2-(phenylimino)-6, 7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one
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Size:
25mg, 5mg
Description
A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase’s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50=1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
1.Kim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.
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