CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-00031-0010-10mg | $95 | ||
| VD-OEIA-00031-0100-100mg | $750 |
NSC 23766
$95.00 – $750.00
Product Specification
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Appearance:
White powder.
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CAS Number:
733767-34-5
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Cat.number:
VD-OEIA-00031
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Formula:
C24H35N7·3HCl
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MW:
530.9
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Purity:
>98%
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Solubility:
H2O (5mg/ml)
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Rac1 Inhibitor
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Size:
100mg, 10mg
Description
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering their interaction with the Rac-specific GEF (guanine nucleotide exchange factor) Trio and Tiam1 (IC50~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Exhibits no effect on Cdc42 or RhoA activation, and does it affect Rac1 interaction with BcrGAP or PAK1.
1.Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 7618-7623.
2.Hable, W.E., et al. 2008. Planta. 227: 991-1000.
3.Yuan, L., et al. 2010. Clin. Exp. Metastasis. 27: 481-491.
4.Raz, L., et al. 2010. PLoS ONE. 5: e12606.
5.Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
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