CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1030-0005-5mg | $150 | ||
| VD-OEIA-1030-0025-25mg | $550 |
NVP-AUY922
$150.00 – $550.00
Product Specification
-
Appearance:
N/A
-
CAS Number:
747412-49-3
-
Cat.number:
VD-OEIA-1030
-
Formula:
C26H31N3O5
-
MW:
465.55
-
Purity:
>98 %
-
Solubility:
N/A
-
Storage:
N/A
-
Synonyms:
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl4-(4- (morpholinomethyl)phenyl)isoxazole-3-carboxamide
-
Size:
25mg, 5mg
Description
Highly potent and oral inhibitor of heat shock protein 90 (Hsp90) in vitro and in vivo, with IC50=21 nM in Hsp90 FP binding assay; inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
1. MR Jensen et al. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 2008, 10, R33.
2. SA Eccles et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Res. 2008, 68, 2850.
3. PA Brough et al. 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. J. Med. Chem., 2008, 51 (2), pp 196–218.
4. T Taldone et al. Targeting Hsp90: small-molecule inhibitors and their clinical development. Cur. Opin. Pharmacol. 2008, 8(4), 370-374.
Reviews
There are no reviews yet.