CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1024-0010-10mg | $155 | ||
| VD-OEIA-1024-0050-50mg | $550 |
PF 431396
$155.00 – $550.00
Product Specification
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Appearance:
Beige solid.
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CAS Number:
717906-29-1
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Cat.number:
VD-OEIA-1024
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Formula:
C22H21F3N6O3S
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MW:
506.5
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Purity:
>=98%
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Solubility:
Soluble to 50 mM in DMSO.
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Storage:
+4°C.
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Synonyms:
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H- indol-5-yl)amino]-5-(trifluoromethyl)-4-pyr imidinyl]amino]methyl]phenyl]methanesulfonamide
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Size:
10mg, 50mg
Description
Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
1.Buckbinder et al (2007). Proc.Natl.Acad.Sci.USA 104 10619.
2.Han et al (2009). J.Biol.Chem. 284 13193.
3.Allen et al (2010). J.Med.Chem. 53 4332.
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