CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0213-0010-10mg | $80 | ||
| VD-OEIA-0213-0050-50mg | $300 |
Pifithrin-α hydrobromide (CAS 63208-82-2)
$80.00 – $300.00
Product Specification
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Appearance:
White solid.
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CAS Number:
63208-82-2
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Cat.number:
VD-OEIA-0213
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Formula:
C16H16N2S.HBr
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MW:
367.3
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Purity:
>98%
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Solubility:
100 mM in DMSO and to 10 mM in ethanol.
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Storage:
-20°C.
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Synonyms:
Pifithrin-alpha
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Size:
10mg, 50mg
Description
Pifithrin-α hydrobromide (CAS 63208-82-2) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). Cyclic analog available (Cat. No. VD-OEIA-0214).
1. Komarov et al (1999) Science 285 1733.
2. Komarova and Gudkov (2000) Biochemistry 65 41.
3. Culmsee et al (2001) J.Neurochem. 77 220.
4. Hoagland et al (2005) J.Pharmacol.Exp.Ther. 314 603.
5. Abdelalim and Tooyama (2012) Biochem.Biophys.Res.Comm. 420 605.
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