CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0215-0025-25mg | $100 | ||
| VD-OEIA-0215-0100-100mg | $350 |
Pifithrin-μ (CAS 64984-31-2)
$100.00 – $350.00
Product Specification
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Appearance:
White solid.
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CAS Number:
64984-31-2
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Cat.number:
VD-OEIA-0215
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Formula:
C8H7NO2S
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MW:
181.21
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Purity:
>99%
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Solubility:
100 mM in DMSO and to 100 mM in Ethanol.
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Storage:
+4˚C.
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Synonyms:
NSC 303580,Pifithrin-mu
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Size:
100mg, 25mg
Description
Pifithrin-μ (CAS 64984-31-2) inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
1. Strom et al (2006) Nat.Chem.Biol. 2 474.
2. Kawamura et al (2009) Nature 460 1140.
3 Leu et al (2009) Mol.Cell 36 15.
4. Steele et al (2009) Blood 114 1217.
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