CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-00094-0005-5mg | $120 | ||
| VD-OEIA-00094-0025-25mg | $500 |
PTP1B Inhibitor
$120.00 – $500.00
Product Specification
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Appearance:
White Solid
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CAS Number:
765317-72-4
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Cat.number:
VD-OEIA-00094
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Formula:
C26H19Br2N3O7S3
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MW:
741.5
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Purity:
≥95% by TLC
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Solubility:
DMSO or EtOH
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Storage:
-20°C. Protect from light.
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Synonyms:
3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran- 6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide
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Size:
25mg, 5mg
Description
PTP1B inhibitor blocks the activity of the Protein Tyrosine Phosphatase 1B, which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones.
1.Sun, T., et al. 2007. Chembiochem. 8: 187-193.
2.Wang, J.F., et al. 2009. Protein Eng. Des. Sel. 22: 349-355.
3.Xu, J.Q., et al. 2010. Bioorg. Med. Chem. 18: 3934-3939.
4.Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540.
2.Wang, J.F., et al. 2009. Protein Eng. Des. Sel. 22: 349-355.
3.Xu, J.Q., et al. 2010. Bioorg. Med. Chem. 18: 3934-3939.
4.Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540.
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