CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-0115-0010-10mg | $85 | ||
| VD-OEIA-0115-0050-50mg | $400 |
RG 108
$85.00 – $400.00
Product Specification
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Appearance:
Yellow, beige solid.
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CAS Number:
48208-26-0
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Cat.number:
VD-OEIA-0115
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Formula:
C19H14N2O4
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MW:
334.3
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Purity:
≥98%
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Solubility:
DMSO or MeOH.
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
DNA Methyltransferase Inhibitor (32675-71-1)
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Size:
10mg, 50mg
Description
A cell-permeable, specific DNA methyltransferases inhibitor (IC50= 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active sit via its carboxy group. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
1.Brueckner et al (2005). Cancer Res. 65 6305.
2.Stresemann et al (2006). Cancer Res. 66 2794.
3.Schirrmacher et al (2006). Bioconjug.Chem. 17 261.
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